Primary Mediastinal Synovial Sarcoma
نویسندگان
چکیده
We report a rare case of a primary mediastinal synovial sarcoma. A 44-year-old man had a well-defined tumor in the left posterior mediastinum involving the left lower lobe of the lung, as detected on chest computed tomography, and underwent an en bloc excision and a left lower lobectomy. Grossly, the tumor measured 8.0 cm in the greatest diameter, with a solid and tan-white cut surface. Histologically, the tumor was mainly composed of spindle-shaped cells with a few foci of epithelial differentiation. Immunohistochemical studies were focally positive for cytokeratin, and diffusely positive for vimentin and bcl-2. Epithelial membrane antigen, S-100 protein, desmin, smooth muscle actin, calretinin, and CD34 were all negative. The SYT-SSX1 gene fusion transcript was detected by a reverse transcriptionpolymerase chain reaction, which was diagnostic of primary synovial sarcoma of the mediastinum. We also reviewed the literature with regard to the clinicopathologic, immunohistochemical, and molecular studies of primary intrathoracic synovial sarcoma. (J Lung Cancer 2008;7(1):29 33)
منابع مشابه
Primary Synovial Sarcoma Presenting as a Huge Mass: A Report of a Rare Case and Review of Literature
Primary synovial sarcoma of mediastinum is very rare among soft tissue sarcomas. Only a few cases have been reportedin the literatures. The best treatment is still unclear, but, surgical resection is the main therapy. In this article we reporta case of a 20*20 cm (2000gr) primary giant mediastinal synovial sarcoma in a 42 year-old man. We performed radicalexcision of the tumor...
متن کاملPrimary intrathoracic biphasic synovial sarcoma.
Synovial sarcomas are most frequently observed in the extremities. Although synovial sarcomas are the third most common histological type of soft-tissue sarcomas of the extremities, primary mediastinal synovial sarcoma is extremely rare. Monophasic synovial sarcoma is the most commonly observed subtype. whereas the biphasic subtype is less common. We present our case which was diagnosed as biph...
متن کاملPrimary mediastinal synovial sarcoma with transdiaphragmatic extension presenting as a pericardial effusion.
Synovial sarcoma is a distinctive soft tissue neoplasm, most commonly seen in the extremities of young adults. Mediastinal synovial sarcoma is a well-documented entity; however, in many cases, the differentiation between this and other spindle cell tumours may be difficult, especially in monophasic tumours. Unlike most pleuropulmonary synovial sarcomas which are well circumscribed, mediastinal ...
متن کاملPrimary mediastinal synovial sarcoma: a case report and review of the literature
Primary mediastinal synovial sarcoma is a rare malignancy with only a few cases reported so far. A 56-year-old woman was admitted to our hospital for an investigation of a nodule in the left middle lung on chest radiography. Computed tomography revealed a mediastinal mass first described as a solitary fibrous tumor. The diagnosis of synovial sarcoma was established by computed tomography-guided...
متن کاملPrimary Mediastinal Synovial Sarcoma
Synovial sarcoma occurs predominantly in the soft tissues of the extremities, but is exceedingly rare in the mediastinum. It has overlapping histological and immunophenotypic features with other tumours in the differential diagnosis. We report a case of a patient who had an incidental finding of such a tumour. Because of the rarity of this tumour in the mediastinum, optimal therapy is unknown a...
متن کامل